Scaffolding to build a rational vaccine design strategy

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Scaffolding to build a rational vaccine design strategy.

C onventional vaccines, going back to the work of Jenner and Pasteur, are based on a rather direct mimicry of the offending pathogen using an attenuated or killed version of the microbe or purified or recombinant proteins from the microbe surface. These vaccines have been enormously successful against a range of pathogens. However, the conventional approaches have faltered for other pathogens, ...

متن کامل

Optimizing rational vaccine design

Amir Aharoni, Department of Life Sciences and the National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel. The size of the microbial world is beyond our imagination. In last year’s crystal ball article, Tom Curtis compared the size of the microbial world to the size of the universe pointing out that the number of microorganisms in the world is billion...

متن کامل

Approaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding

Development of a prophylactic vaccine against hepatitis C virus (HCV) has been hampered by the extraordinary viral diversity and the poor host immune response. Scaffolding, by grafting an epitope onto a heterologous protein scaffold, offers a possible solution to epitope vaccine design. In this study, we designed and characterized epitope vaccine antigens for the antigenic sites of HCV envelope...

متن کامل

a paradigm shift away from method-wise teaching to strategy-wise teaching: an investigation of reconstructive strategy versus communicative strategy

چکیده: هدف اصلی این مطالعه ی توصیفی تحقیقی در حقیقت تلاشی پساروش-گرا به منظور رسیدن به نتیجه ای منطقی در انتخاب مناسبترین راهکار آموزشی بر گرفته از چارچوب راهبردی مطرح شده توسط والدمر مارتن بوده که به بهترین شکل سازگار و مناسب با سامانه ی آموزشی ایران باشد. از این رو، دو راهکار آموزشی، راهکار ارتباطی و راهکار بازساختی، برای تحقیق و بررسی انتخاب شدند. صریحاً اینکه، در راستای هدف اصلی این پژوهش، ر...

15 صفحه اول

FernUniversität’s Strategy to Build a Virtual University

FernUniversität and other distance teaching institutions in Europe and other regions of the world have served for about 25 years an increasing number of predominantly working professionals and students who have other reasons why they cannot attend classroom events. They search for a second chance at higher education combined with the possibility to study flexibly at the time and location of the...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2010

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1012923107